There are plenty of well thought-out advice books and blogs for entrepreneurs on what to do to succeed. Equally important, and in away a corollary to these advices, are critical mistakes that entrepreneurs need to avoid losing their business. Not all mistakes will kill a company and many in fact could strengthen the start-up, but after examining dozens of company failures, I have come up with a list of ten crucial areas that accounts for all the company failures I examined. The challenge for entrepreneurs is how to avoid these mistakes but the first step is to be aware and mindful of these hazards. That’s why for each mistake I have also listed common “symptoms” to help spot the problem. It is also a checklist for me, as a venture investor, to see what is the likelihood of company failure based on any of these factors, and how I should account for that risk in the investment valuation.